Because supplements are not regulated in most countries, many providers don’t go through the hassle and expense of quality control to verify the safety and tolerability of their active ingredients.
Rather than provide transparency through rigorous assessment and testing, it is common to create an image based on vague statements about features like purity. But it is transparency through testing that is more reliable marker of NMN quality.
One way to judge if a brand’s NMN has undergone expert assessment is if it has been granted Self-GRAS status. This means that a panel of food nutrition specialists have deemed it Generally Recognized as Safe (hence the term GRAS) in accordance with stringent US FDA regulatory guidelines.
For example, in November 2020 an independent panel of toxicology and nutrition experts rigorously evaluated research studies and toxicology data on our proprietary form of nicotinamide mononucleotide, called NMN-C®
. They concluded that it is not harmful under its intended conditions of use, which resulted in NMN-C® receiving Self-GRAS status. This endorsement not only adds an extra level of validity to the ingredient in the eyes of the industry, but also provides consumers with additional validation of quality and safety.
Brands that take safety seriously test their own products and publish the results. This ensures they have the most accurate information possible about dosage and tolerability for a specific product, which in turn delivers peace of mind and better safety outcomes for consumers.
An example of this kind of scrutiny is a toxicology study
that we undertook on NMN-C®. The study analyzed the No Observable Adverse Effect Level (NOAEL). Establishing the exact NOAEL for our specific form of NMN enables us to know precisely the upper tolerability levels for males and females, which informs our guidance around dosage. It also demonstrated that NMN-C® is an extremely well-tolerated option in comparison to other common NAD+ (nicotinamide adenine dinucleotide) boosters.
Without undertaking testing on our own NMN, we would not know the exact toxicology profile of our molecule. Unfortunately for consumers, this level of analysis and transparency is not widespread within the NAD+ boosting and supplement industries.